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. 2006 Jul 28;66:193–292. doi: 10.1016/S0065-3527(06)66005-3

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Copyright © 2006 Elsevier Inc. All rights reserved.

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Fig 2 — The spike (S) protein. At the right is a linear map of the protein, denoting the amino‐terminal S1 and the carboxy‐terminal S2 portions of the molecule. The arrowhead marks the site of cleavage for those S proteins that become cleaved by cellular protease(s). The signal peptide and regions of mapped receptor‐binding domains (RBDs) are shown in S1. The heptad repeat regions (HR1 and HR2), putative fusion peptide (F), transmembrane domain, and endodomain are indicated in S2. At the left is a model for the S protein trimer.