Fig 3.

Effect of infections on epithelia. Viral toxicities calculated from the amount of LDH released by damaged cells in the basal medium (n = 8; A) and TEER (n ≥ 2; B) were measured at days 2 and 5 post infection (p.i.). The 48-hour time point represents LDH accumulated during 48 hours; for later time points, the medium was replaced every day, and data correspond to LDH secretions within the preceding 24 hours. Dotted lines in Fig 3, B, correspond to the established threshold of tissue integrity. *P < .05, **P < .01, and ***P < .001. Asterisks in light gray show statistical significance relative to noninfected tissue, whereas black asterisks show statistical significance compared with all other respiratory viruses at each time point.