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Amyloidogenic processing of APP and formation of amyloid (Aβ) peptide, fibrils, and plaques. Main avenues in neurodegeneration and neuroprotection. APP, amyloid precursor protein; sAPPα, soluble product of α‐secretase cleavage; sAPPβ, soluble product of β‐secretase cleavage; AICD, C‐terminal fragment of APP, product of γ‐secretase cleavage.
