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Activity-based probes to target DUB specificity. (A) monoUb-PA probe. (B) Details of “in-between” diUb probe. (C) Details of “proximal” diUb probe. (D) Different probes targeting S1, S1–S1′ or S1–S2 interactions. (E) Misalignment of probes on DUBS prevents formation of covalent complexes.
