Table.
Effect of Interferons on virus-induced cytopathogenic effects of SARS-CoV and vesicular stomatitis virus
| Mean (SD) EC50 (IU/mL)* | CC50 (IU/mL) | Selectivity index | |||||
|---|---|---|---|---|---|---|---|
| SARS-CoV FFM-1 | SARS-CoV Hong Kong | VSV Indiana | SARS-CoV FFM-1 | SARS-CoV Hong Kong | VSV Indiana | ||
| Vero† | |||||||
| Interferon α | 4950 (890) | 6500 (980) | 638 (98) | >10000 | >2 | >1·5 | >16 |
| Interferon β | 95 (17) | 105 (21) | 18·0 (3·7) | >10000 | >105 | >95 | >556 |
| Interferon γ | 2500 (340) | 1700 (290) | 508 (62) | >10000 | >4 | >5·9 | >20 |
| Caco2† | |||||||
| Interferon α | 1530 (220) | 880 (130) | 3700 (420) | >10000 | >6·5 | >11·4 | >2·7 |
| Interferon β | 21·0 (3·9) | 9·2 (2·1) | 1030 (150) | >10000 | >476 | >1087 | >9·7 |
| Interferon γ | >10000 | >10000 | >10000 | >10000 | NC | NC | NC |
VSV=vesicular stomatitis virus. NC=not calculable
*
Mean (SD) of eight assays.
†
Cells treated with interferons 24 h before and during virus infection.