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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Cancer Res. 2020 Jan 16;80(5):1078–1087. doi: 10.1158/0008-5472.CAN-19-2039

Figure 4. Pair correlation functions (PCF) reveal differences in clustering between tumor and immune cells.

Figure 4.

(A) Non-recurrent patients have higher degrees of clustering between tumor cells and CTLs as well as with HLA-DR+ macrophages. Shaded regions indicate 95% confidence intervals of the median PCF obtained via bootstrapping. (B) Representative false-color images with the 3 lowest and 3 highest PCF values for each of the Tumor-CTL and Tumor Macrophage interactions. To the right of each image is a rendition of its cell segmentation, depicting Tumor (Red), CTL (Blue), Macrophage (Green), and Other (Gray). Statistical analysis performed using Mann-Whitney U test on PCF areas under the curve (AUC).