Table 2. Top genes from MIP.
Top 9 immune genes that are significantly increased in patients with good DSS after Benjamini-Hochberg correction and correlation of these genes with qmIF data for stromal density of CD3, CD3+CD8+, and CD68+ as well as ratio of CD8/CD68. Values in bold are different from 0 with a significance level alpha=0.05 using Benjamini-Hochberg correction.
Differential expression | Correlation with Density | |||||
---|---|---|---|---|---|---|
Gene | Fold Change | BH p value | CD8/CD68 Stroma | CD3+CD8+ Stroma | CD68+ Stroma | CD3+ Stroma |
PTPRC | 1.07 | 0.0399 | 0.05 | 0.17 | 0.12 | 0.3 |
CCL5 | 1.19 | 0.0399 | 0.21 | 0.36 | 0.03 | 0.41 |
CD2 | 1.05 | 0.0399 | 0.07 | 0.24 | 0.14 | 0.36 |
CD27 | 1.21 | 0.04 | 0.04 | 0.2 | 0.16 | 0.31 |
CXCL9 | 1.56 | 0.0459 | 0.19 | 0.33 | 0.04 | 0.45 |
CD8A | 1.26 | 0.0459 | 0.16 | 0.35 | 0.11 | 0.39 |
CXCR3 | 1.11 | 0.0459 | 0.19 | 0.36 | 0.06 | 0.4 |
CXCL11 | 1.39 | 0.0459 | 0.2 | 0.38 | 0.05 | 0.42 |
LCK | 1.14 | 0.0459 | −0.03 | 0.12 | 0.21 | 0.24 |