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. 2016 Apr 26;163:1–23. doi: 10.1016/j.pharmthera.2016.03.018

Table 1.

Properties of peroxiredoxin isoforms.

PRDX1-4 PRDX5 PRDX6
Class 2-cys Atypical 2-cys 1-cys
Thioredoxin fold superfamily Yes Yes Yes
Structure of disulphide bond Homodimer Monomer Heterodimer
Reductant Trx Trx GSH
PLOOH as substrate No No Yes
PLA2 activity No No Yes

PLOOH, phospholipid hydroperoxide.