Table 3.

Summary of function of PRDX subfamily in different neurodenerative disease types

PRDX type	Disease type	Effects	Results	Mechanisms	Reference
PRDX1 PRDX2	Sporadic Creutzfeldt-Jacob disease	Neuroprotective effect	Decrease the disease	PRDX1 is decreased in the frontal cortex of patients with Sporadic Creutzfeldt-Jacob disease	Krapfenbauer, Yoo, Fountoulakis, Mitrova, & Lubec, 2002
	Neuroblastoma	Neurodegenerative effect	Enhance the neuroblastoma	PRDX1 is induced by the accumulation of Aβ1-42 peptides in neuroblastoma cells	Lee et al., 2011
	AD	Neuroprotective effect	Protects the brain	PRDX2 is overexpressed in the brain of AD patients indicating that PRDX2 protects the brain from Aβ1-42 induced neurotoxicity	Cimini et al., 2013
	PD	Neurodegenerative effect	Increase the risk of PD	-PRDX2 is involved in the regulation of 6-OHDA-induced apoptosis signaling in DA induced neuronal cell death -PRDX2 phosphorylation is involved in PD -PRDX2 promotes oxidative stress-induced neuronal cell death in PD	Hu et al., 2011, Qu et al., 2007, Fang et al., 2007
PRDX3	Excitotoxic injury	Neuroprotective effect	Protects the neuron	PRDX3 is involved in the protection of hippocampal neurons from excitotoxic injury	Hattori et al., 2003
	Down syndrome	Neuroprotective effect	Protects the brain from Down syndrome	PRDX3 is decreased in frontal cortex of Down syndrome	Krapfenbauer et al., 2003
	Pick’s disease	Neuroprotective effect	Protects the brain from Pick’s disease	PRDX3 is decreased in frontal cortex of Pick’s disease	Krapfenbauer et al., 2003
	PD	Neurodegenerative effect	Increase the risk of PD	PRDX3 phosphorylation is increased in autosomal dominant mutation of LRRK2 that is important for PD and results in the oxidative stress induced neuronal death	Angeles et al., 2011
PRDX4	Pick’s disease	Neurodegenerative effect	Increase the risk of Pick’s disease	PRDX4 is significantly increased only in Pick’s disease frontal cortex	Krapfenbauer et al., 2003
PRDX5	PD	Neurodegenerative effect	Increase the risk of PD	PRDX5 is involved in PD through mitochondrial redox signaling with Ca2 + influx resulting in the development of PD	Davey & Bolaños, 2013
PRDX6	AD	Neurodegenerative effect	Increase the risk of AD	-PRDX6 accelerates the development of AD through increased amyloidogenesis through independent PLA2 activation and Nrf2 transcription. - PRDX6 activates astrocyte and microglia cells, lipid peroxidation and protein carbonyl levels in PRDX6 overexpressed transgenic mice.	Shalini et al., 2014, Yun et al., 2013
	PD	Neurodegenerative effect	Increase the risk of PD	PRDX6 induces astrocytic activation followed by increased proinflammatory cytokines (TNF-α and IL1-β), 4-HNE, and PRDX6 hyperoxidation in primary cultured astrocytes.	Yun et al., 2015c, Yun et al., 2015b, Yun et al., 2015a