Table 4.

Summary of function of PRDX subfamily in different inflammatory disease types

PRDX type	Disease type	Effects	Results	Mechanisms	Reference
PRDX1	Atherosclerosis	Benefit effect	Protects against atherosclerosis	PRDX1 is induced by exposing macrophages to oxidized LDL5 and by laminar shear stress in endothelial cells PRDX1 protects against excessive endothelial activation and atherosclerosis	Kisucka et al., 2008; Mowbray et al., 2008
	Rheumatoid arthritis	Non-benefit effect	Enhance the risk of RA	PRDX1 is overexpressed in RA patient tissue by more than 3 fold compared with normal tissues.	Li et al., 2013
PRDX2	Atherosclerosis	Benefit effect	Suppresses Atherosclerosis	PRDX2 suppresses the proliferation and migration of SMCs through the site-selective phosphorylation of the PDGF receptor and, furthermore, is involved in the neointimal thickening of SMCs in balloon-injured carotidartery	Kang et al., 2013
	Rheumatoid arthritis	Non-benefit effect	Enhance the risk of RA	PRDX2 is involved in the persistence of pro-inflammatory cells in chronic inflammation because PRDX2 protein content of lymphocytes from RA patient was more than 2-fold higher compared with healthy lymphocytes	Szabó-Taylor et al., 2012
PRDX3	Obesity	Benefit effect	Decrease the risk of obesity	PRDX3 deficiency increased abnormal lipid accumulation in adipose tissue, due to increased ROS	Huh et al., 2012
PRDX4	Atherosclerosis	Benefit effect	Protects against atherosclerosis	PRDX4 protects the vascular tissue against ROS and hence, it has ability to inhibit the oxidative stress induced inflammation in various tissues	Guo et al., 2012
		Non-benefit effect	Enhance the risk of RA	PRDX4 is increased in synovial tissues of RA patients	Chang et al., 2009
	Rheumatoid arthritis	Benefit effect	Decrease the risk of obesity	PRDX4 prevents HFD-induced hepatic steatosis and insulin resistance by amelioration of oxidative stress in PRDX4 overexpressed transgenic mice	Ding et al., 2010
	Obesity	Benefit effect	Protects against atherosclerosis	PRDX6-/- macrophages oxidized LDL significantly more than did controls and plasma lipid hydroperoxide levels were higher in atherogenic diet-fed Prdx6-/- mice than in controls.	Wang et al., 2004
PRDX6	Rheumatoid arthritis	Non-benefit effect	Enhance the risk of RA	PRDX6 promotes development of RA through activation of NF-κB/AP-1 coupled JNK pathway in the CAIA and AIA-induced arthritis development model	Kim et al., 2015