Table 4.
PRDX type | Disease type | Effects | Results | Mechanisms | Reference |
---|---|---|---|---|---|
PRDX1 | Atherosclerosis | Benefit effect | Protects against atherosclerosis | PRDX1 is induced by exposing macrophages to oxidized LDL5 and by laminar shear stress in endothelial cells PRDX1 protects against excessive endothelial activation and atherosclerosis |
Kisucka et al., 2008; Mowbray et al., 2008 |
Rheumatoid arthritis | Non-benefit effect | Enhance the risk of RA | PRDX1 is overexpressed in RA patient tissue by more than 3 fold compared with normal tissues. | Li et al., 2013 | |
PRDX2 | Atherosclerosis | Benefit effect | Suppresses Atherosclerosis | PRDX2 suppresses the proliferation and migration of SMCs through the site-selective phosphorylation of the PDGF receptor and, furthermore, is involved in the neointimal thickening of SMCs in balloon-injured carotidartery | Kang et al., 2013 |
Rheumatoid arthritis | Non-benefit effect | Enhance the risk of RA | PRDX2 is involved in the persistence of pro-inflammatory cells in chronic inflammation because PRDX2 protein content of lymphocytes from RA patient was more than 2-fold higher compared with healthy lymphocytes | Szabó-Taylor et al., 2012 | |
PRDX3 | Obesity | Benefit effect | Decrease the risk of obesity | PRDX3 deficiency increased abnormal lipid accumulation in adipose tissue, due to increased ROS | Huh et al., 2012 |
PRDX4 | Atherosclerosis | Benefit effect | Protects against atherosclerosis | PRDX4 protects the vascular tissue against ROS and hence, it has ability to inhibit the oxidative stress induced inflammation in various tissues | Guo et al., 2012 |
Non-benefit effect | Enhance the risk of RA | PRDX4 is increased in synovial tissues of RA patients | Chang et al., 2009 | ||
Rheumatoid arthritis | Benefit effect | Decrease the risk of obesity | PRDX4 prevents HFD-induced hepatic steatosis and insulin resistance by amelioration of oxidative stress in PRDX4 overexpressed transgenic mice | Ding et al., 2010 | |
Obesity | Benefit effect | Protects against atherosclerosis | PRDX6-/- macrophages oxidized LDL significantly more than did controls and plasma lipid hydroperoxide levels were higher in atherogenic diet-fed Prdx6-/- mice than in controls. | Wang et al., 2004 | |
PRDX6 | Rheumatoid arthritis | Non-benefit effect | Enhance the risk of RA | PRDX6 promotes development of RA through activation of NF-κB/AP-1 coupled JNK pathway in the CAIA and AIA-induced arthritis development model | Kim et al., 2015 |