Table 2.
Duration of hospitalisation (in days) by Ct value (viral load) for all patient and individual clinical groups, by virus subtype.
| Ct value (viral load) |
p Valuea | p Valueb | ||||
|---|---|---|---|---|---|---|
| ≤20 | 21–25 | 26–30 | >30 | |||
| All patients (n) | ||||||
| All viruses (306) | 6 [2–10] | 2 [1–5] | 2 [1–4] | 2 [1–5] | 0.0002 | <0.0001 |
| Influenza (73) | 7 [2.5–13.5] | 2 [1–3.8] | 2 [1–4] | 2.5 [1–6] | 0.019 | 0.005 |
| Rhino/entero (149) | 4 [2–7.8] | 2 [1–4.3] | 2 [1–4] | 2 [1–4] | 0.052 | 0.004 |
| Other virusesc (84) | 6 [2.5–13] | 4 [1.5–8] | 3 [1–6] | 3.5 [1–5.5] | 0.236 | 0.044 |
| Asthma | ||||||
| All viruses (95) | 4 [1.8–7] | 2 [1–3] | 2 [1–4] | 1 [1–2.3] | 0.086 | 0.016 |
| Influenza (19) | 2 [2–2] | 2 [1–3] | 3 [1–4.3] | 2 [1–3.5] | NA | NA |
| Rhino/entero (58) | 4 [1.3–7] | 1 [1–2] | 1 [1–3.3] | 1 [1–2] | 0.071 | 0.006 |
| Other virusesc (18) | 7 [7–7] | 3 [1.5–7.5] | 2 [1–6.3] | 3 [2–4] | NA | NA |
| IECOPD | ||||||
| All viruses (108) | 6 [3–13.5] | 4 [1–7] | 3 [1–6] | 2 [1–5.5] | 0.089 | 0.020 |
| Influenza (20) | 8.5 [6–17.5] | 2 [1–5.5] | 2 [1–6] | 3 [1.5–6.5] | 0.078 | 0.007 |
| Rhino/entero (47) | 4.5 [3–6] | 4 [1–8] | 2.5 [1–6] | 2 [1–6] | 0.386 | 0.574 |
| Other virusesc (41) | 4 [2–17] | 4 [1.5–8] | 4.5 [1.5–5.8] | 4 [1–6] | 0.919 | 0.542 |
| CAP | ||||||
| All viruses (56) | 14.5 [3.8–20] | 5 [2.5–11] | 3 [2–11] | 3 [1–6] | 0.077 | 0.012 |
| Influenza (23) | 17 [3–21] | 6.5 [1–12] | 1.5 [1–2] | 7.5 [3–9] | 0.073 | 0.028 |
| Rhino/entero (30) | 14 [2–30] | 4.5 [4–5] | 3.5 [2.3–14] | 3 [1–5.5] | 0.415 | 0.249 |
| Other virusesc (13) | 10.5 [6–15] | 10 [10–10] | 11 [3–23] | 2 [1–12] | NA | 0.423 |
| ILI/bronchitis | ||||||
| All viruses (47) | 3 [2–8] | 1.5 [1–5.5] | 1 [1–3] | 1.5 [1–5.5 | 0.098 | 0.025 |
| Influenza (21) | 3 [1–8] | 1 [1–8.5] | 1 [1–3.5] | 2.5 [1–6.3] | 0.807 | 0.493 |
| Rhino/entero (14) | 3 [2–8] | 1 [1–1] | 1 [1–2.8] | 1.5 [1–2] | NA | NA |
| Other virusesc (12) | 8 [2–11] | 3 [1–7] | 1 [1–4] | NA | NA | 0.155 |
Data are presented as median [Inter-quartile range].
Abbreviations: Ct; real-time PCR cycle threshold (a low Ct value represents a high viral load and vice versa); CAP, community acquired pneumonia; IECOPD, infective exacerbation of COPD; ILI, influenza-like illness; NA, not applicable.
p values highlighted in bold are statistically significant (i.e., p.<0.05).
a
Across all groups (Kruskal–Wallis test).
b
Between high viral load group (Ct ≤ 20) and other groups combined (Chi squared).
c
Includes; Respiratory Syncytial Virus, parainfluenza 1–4, human metapneumovirus, coronavirus and adenovirus.