Table 3.
Variable | Ratio | 95% CI | p Value | |
---|---|---|---|---|
Ct valuea | 0.94 | 0.92 | 0.97 | <0.001 |
Agea | 1.02 | 1.01 | 1.04 | <0.001 |
Duration of illness prior to admission, days | 0.99 | 0.93 | 1.07 | 0.965 |
Sex (reference group: female) | 0.80 | 0.58 | 1.11 | 0.181 |
Influenza vaccine (reference group: no) | 0.94 | 0.67 | 1.31 | 0.700 |
Comorbidity (reference group: none) | 1.47 | 1.05 | 2.07 | 0.025 |
Antibiotics prior to admission (reference group: none) | 1.12 | 0.78 | 1.60 | 0.544 |
Current smoker (reference group: no) | 1.11 | 0.78 | 1.58 | 0.563 |
Bacterial detection (reference group: no) | 1.78 | 1.18 | 2.67 | 0.006 |
Clinical group | ||||
Asthma (reference group) | – | – | – | – |
IECOPD | 1.16 | 0.72 | 1.85 | 0.538 |
Pneumonia | 1.44 | 0.79 | 2.63 | 0.236 |
ILI/bronchitis | 0.46 | 0.21 | 0.98 | 0.044 |
Virus type | ||||
Influenza (reference group) | – | – | – | – |
Rhino/enterovirus | 0.92 | 0.62 | 1.38 | 0.692 |
Other virusesb | 1.12 | 0.74 | 1.70 | 0.588 |
Abbreviations: Ct, real-time PCR Cycle threshold (a low Ct value represents a high viral load and vice versa); IECOPD, infective exacerbation of COPD; CAP, community acquired pneumonia; ILI, Influenza-like illness; CI, confidence interval.
Note: For each unit decrease in Ct value (i.e. increase in viral load), there is a 6% increase in expected days in hospital. Likewise, for each additional year of age, length of stay increases by 2%. The presence of at least one of any recorded comorbidity (cardiovascular, renal or liver disease, malignancy or diabetes) increases length of stay by 47% relative to people without any of these comorbidities. The detection of bacteria was associated with a 78% increase in length of stay. Patients with ILI/bronchitis had a length of stay 46% shorter than those with asthma.
p values highlighted in bold are statistically significant (i.e., p <0.05).
Variables are mean-centred.
Includes; Respiratory Syncytial Virus, parainfluenza 1–4, human metapneumovirus, human coronavirus and adenovirus.