Fig. 3.

Protein-protein interaction networks of deiminated protein hits identified in whole llama (Lama glama) serum. Reconstruction of protein-protein interactions based on known and predicted interactions using STRING analysis. Due to annotations for camelids not being present in STRING, proteins are based on corresponding human protein identifiers. A. Coloured nodes represent query proteins and first shell of interactors; white nodes are second shell of interactors. B. Biological GO processes are highlighted for the same protein network as follows: red = response to stress; blue = response to wounding; green = vesicle mediated transport; yellow = oxygen transport; purple = regulated exocytosis; dark green = small molecule metabolic process. Coloured lines indicate whether protein interactions are identified via known interactions (curated databases, experimentally determined), predicted interactions (gene neighbourhood, gene fusion, gene co-occurrence) or via text mining, co-expression or protein homology (see colour key for connective lines in A).