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. 2019 Jul 24;114:100–107. doi: 10.1016/j.molimm.2019.07.003

Fig. 3.

Fig. 3

PDCoV nsp15 inhibits IFN-β production independently of its endoribonuclease activity. LLC-PK1 cells (A) or HEK-293T cells (B) cultured in 24-well plates were transfected with 1.0 μg of expression plasmid (PDCoV nsp15, H219A, H234A, or K269A) or empty vector, along with IFN-β-Luc and pRL-TK for 24 h. The cells were then mock-infected or infected with SEV for 12 h and subjected to dual-luciferase reporter assays. Data are means ± SD from three independent experiments. ***, p <  0.001; **, p <  0.01; *, p <  0.05.