Table 2.
Inhibitory effect of mycophenolic acid, ribavirin, and interferons on MERS-CoV replication in Vero cell yield reduction assay.
| Drug | EC50 | EC90 | EC99 | CC50 | Selectivity indexa |
|---|---|---|---|---|---|
| Mycophenolic acid (μg/ml) | |||||
| Alone | 0.17 ± 0.03 | 2.61 ± 0.34 | 4.86 ± 0.57 | >32 | >195.12 |
| With 6.25 IU/ml Betaferon | 0.10 ± 0.01 | ||||
| With 12.5 IU/ml Betaferon | 0.06 ± 0.01 | ||||
| Ribavirin (μg/ml) | 9.99 ± 2.97 | 107.06 ± 11.24 | 183.17 ± 11.97 | >1600 | >152.98 |
| Intron A (IU/ml) | 6709.79 ± 1747.97 | 184015.75 ± 90145.01 | 371242.78 ± 255482.32 | >75,000 | >11.73 |
| Avonex (IU/ml) | 5073.33 ± 7333.86 | 179949.17 ± 138588.37 | 708919.75 ± 840503.36 | >75,000 | >35.19 |
| Rebif (IU/ml) | 480.54 ± 183.85 | 2473.86 ± 576.35 | 3599.06 ± 778.81 | 15,625 | 27.08 |
| Betaferon (IU/ml) | |||||
| Alone | 17.64 ± 1.09 | 93.31 ± 10.07 | 135.70 ± 15.96 | 3125 | 249.09 |
| With 0.016 μg/ml of mycophenolic acid | 16.09 ± 4.09 | ||||
| With 0.063 μg/ml of mycophenolic acid | 9.80 ± 0.53 | ||||
a
Selectivity index defined as ratio of CC50/EC50.