Skip to main content
. 2010 Jul 3;128(1):119–128. doi: 10.1016/j.pharmthera.2010.06.003

Fig. 3.

Fig. 3

Post-translational modifications of ACE2; internalization and shedding. SARS coronavirus (SARS-CoV) binds to and internalizes with ACE2 for its cellular entry in a Clathrin-dependent manner. Membrane fusion is mediated via activation of Spike by proteases, such as trypsin or furin, and viral RNAs are released into cytoplasm, establishing SARS infection. The transmembrane proteinase (ADAM17) cleaves the extracellular juxtamembrane region of ACE2, releasing the catalytically active ectodomain into the extracellular milieu. Whether such ACE2 cleavage contributes to SARS pathogenesis is not known yet.