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. 2019 Jan 9;2019(1):CD001118. doi: 10.1002/14651858.CD001118.pub4

Humerfelt 1998.

Methods Setting: community, Norway
 Recruitment: from participants in a community survey of men aged 30 to 45 years who had increased risk of obstructive lung disease or lung cancer
Participants 2610 men who smoked with reduced FEV₁ and/or occupational asbestos exposure, average age 37, average cpd 16
Interventions ∙ Mailed self‐help pamphlet (15 pages), emphasising behavioural modification techniques in smoking cessation and recommending an early quit date, accompanied by a letter from a respiratory physician advising of high risk status established by the survey
 ∙ No intervention
Outcomes Abstinence at 15 months (point prevalence)
 Validation: participants in 1 geographical area invited for CO measurement (CO < 10 ppm)
Notes For meta‐analysis, the number of quitters has been adjusted for the validated rate found in the sample tested (63% in intervention/67% in control)
Participants who stopped smoking before receiving materials were included
Study authors give 12 months' sustained abstinence rates of 5.6% vs 3.5%, but these rates are based on self‐report by responders
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Randomised; method not described
Allocation concealment (selection bias) Unclear risk No details given
Blinding (performance bias and detection bias) 
 All outcomes Low risk Control group not aware of intervention received by intervention group; biochemical validation conducted in subset of participants; no significant difference in misreport detected (1 intervention, 2 control)
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Loss to follow‐up greater in the intervention group (17%) than in the control group (8%)
The probability of responding to the follow‐up questionnaire was inversely related to baseline cpd consumption in the intervention group but not in the control group
Losses included as smokers