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. 2020 Apr 1;6(14):eaay3245. doi: 10.1126/sciadv.aay3245

Fig. 6. IL-27 signaling reduces the severity and occurrence of in vivo neurological symptoms due to Zika virus infection in the absence of type I IFN signaling.

Fig. 6

Bar graphs detailing morbidity and mortality of B6 (WT), Ifnar1KO, Il27raKO, and Ifnar1/Il27ra dKO injected subcutaneously with Zika virus (HPF2013 strain) at 5 to 10 days after infection. Symptoms were scored in a sequential fashion, where lesser symptoms (e.g., hunched, unkempt fur) were not counted if a mouse presented with more severe symptoms (e.g., hindleg weakness). n = 10 to 12 mice (B6), 12 to 14 mice (Il27raKO), 14 to 16 mice (Ifnar1KO), and 11 to 12 mice (Ifnar1/Il27ra dKO) per experimental group. Experiment was repeated three times.