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. 2020 Apr 1;6(14):eaba0145. doi: 10.1126/sciadv.aba0145

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 2 — (A) Schematic view of OraEx4 synthesis, including loading of LCFA-Ex4 into DOPA liposome (Lipo) and sequential coating with chitosan nanoparticle (ChiNP). Chito, chitosan; TPP, sodium triphosphate; DOPA, 1,2-dioleoyl-sn-glycero-3-phosphate; Chole, cholesterol; LCFA,16-hydroxyhexadecanoic acid; Ex4, exendin-4. (B) Zeta potential and size of ChiNP, Lipo, and ChiNP-Lipo. (C) Transmission electron microscopy (TEM) images of ChiNP-Lipo with increasing ChiNP/Lipo ratio. (D) Fourier-transform infrared (FT-IR) spectra of ChiNP, Lipo, and ChiNP-Lipo under different pH environments. (E) Changes in hydrodynamic radius of ChiNP-Lipo under different pH conditions. (F) Release profiles of LCFA-Ex4 from OraEx4 and conventional liposome (T-Lipo). (G) TEM images of OraEx4 at different pH. Data are presented as means ± SEM.