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. 2011 Sep 9;30(10):1587–1597. doi: 10.1016/j.trac.2011.08.006

Table 1.

Purified pathogen molecules that have been used in selection of aptamers by SELEX

Target molecules Ref.
HIV-1
Integrase [14]
Reverse transcriptase [15], [16]
Nucleocapsid protein [17], [18]
Tat protein [19]
R5 SV glycoprotein (gp120) [20], [21]
Drug-resistant reverse transcriptase [22]



Hepatitis C virus
RdRp [23]
NS3 [24]
NS3 helicase [25], [26]
3′X tail [27]
NS3 protease [26], [28]
NS5B RNA polymerase [29]
IRES (internal ribosome entry site) [27], [30]



Hepatitis B virus
HBsAg surface antigen [31]



Influenza virus
H5N1 HA protein [32]



SARS coronavirus
NTPase, Helicase [33], [34]



Apple stem pitting virus
Coat proteins [35]



Foot and mouth disease virus
VP1 protein [36]



Prion proteins
PrPsc [37]
PrPsc fibrils [38]
rPrPsc [39]
rPrPc [40]
Mammalian prion proteins [41]



Escherichia coli
Release factor 1 [42]
Core RNA Polymerase [43]
Lipopolysaccharide O111: B4 [10], [11]



Mycobacterium
M. avium sub. paratuberculosis MAP0105c gene product [44]
M. tuberculosis MPT64 protein [45]
M. tuberculosis polyphosphate kinase 2 [46]



Francisella tularensis
Protein lysate [47]



Campylobacter jejuni
Surface extract [48]
Protein lysate [49]



Salmonella enterica
serovar Typhi Type IVB pilus [50]
Outer membrane proteins [51]



Listeria monocytogenes
Internalin A [52]



Leishmania infantum
H2 Antigen [53]



Burkholderia pseudomallei
BipD/BopE/BPSL2748 [54]



Ustilago maydis [corn pathogen]
RNA-binding protein Rrm4 [55]



Venezuelan equine encephalitis virus
Capsid protein [56]



Bacterial toxins
Staphylococcal enterotoxin B, Cholera toxin [57]
Botulinum neurotoxin [58], [59]
Shiga toxin [59]