Fig. 2.

Chemokines regulate NK cell cross-talk with other immune cells in lymphoid and non lymphoid tissues. NK cells functional interaction with DC, monocytes or tissue resident machrophages can be facilitated by tissue expression of chemokines that promote simultaneous recruitment of cells from circulation facilitating their communication in vivo. In addition, several in vitro studies have evidenced the role of chemokines produced by NK cells and other immune cells, including CCR5, CXCR3 and XCL1 ligands for reciprocal attraction.