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CD46 co-stimulation promotes proliferation of CD8+ T cells. Isolated CD8+ and CD4+ T cells, respectively, were incubated with CFSE and stimulated with either αCD3/αCD28 or αCD3/αCD46 for 72 h. (A) Flow histograms of the CFSE fluorescence intensity in CD8+ and CD4+ T cells from a representative donor (n = 6 donors). (B) Frequency of proliferating cells represented as mean ± SD of 6 donors. Data were analyzed using Wilcoxon signed rank test, * p < 0.05. NA = no antibodies.
