Table 4.
Transgender Female (n = 11) | Cisgender Female (n = 23†) | Transgender Female (n = 13) | Cisgender Male (n = 24†) | |
---|---|---|---|---|
Age | 16.2 ± 1.2 | 16.0 ± 1.3 | 16.2 ± 1.4 | 16.1 ± 1.6 |
BMI (%) | 55 ± 34 | 58 ± 30 | 46 ± 37 | 45 ± 36 |
Systolic BP (mm Hg) | 107 ± 12 | 113 ± 7 | 106 ± 11 | 116 ± 8** |
Diastolic BP (mm Hg) | 70 ± 7 | 66 ± 7 | 70 ± 6 | 67 ± 5 |
Inverse of fasting insulin (mL/μU) | 0.066 ± 0.02 | 0.098 ± 0.045 | 0.078 ± 0.025 | 0.142 ± 0.064* |
HOMA-IR | 3.8 ± 2.1 | 2.8 ± 1.4 | 3.4 ± 2.2 | 2.1 ± 1.2* |
Fasting glucose (mg/dL) | 89 ± 5 | 82 ± 12 | 90 ± 4 | 86 ± 6 |
Hemoglobin A1C (%) | 5.2 ± 0.4 | 5.0 ± 0.2 | 5.2 ± 0.4 | 5.1 ± 0.3 |
AST (U/L) | 37 ± 4 | 23 ± 6*** | 37 ± 4 | 34 ± 18 |
ALT (U/L) | 25 ± 5 | 26 ± 6 | 24 ± 5 | 32 ± 21 |
Total cholesterol (mg/dL) | 148 ± 23 | 145 ± 20 | 152 ± 22 | 136 ± 25 |
Triglycerides (mg/dL) | 77 ± 34 | 74 ± 21 | 81 ± 34 | 97 ± 30 |
HDL (mg/dL) | 49 ± 10 | 46 ± 10 | 50 ± 10 | 43 ± 6* |
LDL (mg/dL) | 83 ± 20 | 84 ± 20 | 85 ± 20 | 74 ± 22 |
Total estradiol (pg/mL) | 98 ± 135 | 96 ± 127 | 124 ± 162 | 23 ± 9** |
Total testosterone (ng/dL) | 224 ± 182 | 43 ± 10*** | 252 ± 214 | 412 ± 168* |
LH (mIU/mL) | 3.6 ± 3.2 | --- | 3.5 ± 2.9 | --- |
FSH (mIU/mL) | 2.1 ± 1.9 | --- | 1.9 ± 1.8 | --- |
SHBG (nmol/L) | 49 ± 36 | 50 ± 30 | 50 ± 48 | 40 ± 16 |
Free androgen index | 33 ± 36 | 5 ± 3** | 36 ± 34 | 37 ± 16 |
Values are given as mean ± SD. Of the 11 transgender females compared with cisgender females and the 13 compared with cisgender males, 10 are in both comparisons. BP = blood pressure, LH = luteinizing hormone, FSH = follicle stimulating hormone, †means and standard deviations are reported for the 11 matched sets for cisgender females and 13 matched sets for cisgender males, *P < 0.05, **P ≤ 0.01, ***P ≤ 0.001 (p-values represent significance from log-transformed variables when relevant)