Table 4.
Binary logistic regression analysis investigating FSTL3 and IGF-1 to intact IGFBP3 as independent associates of NASH and histologic lesions within NAFLD patients (n = 31).
| Logistic regression Model variables | Model 1 (unadjusted) | Model 2 (BMI) | Model 3 (BMI, age) | Model 4 (BMI, age, gender) | Model 5 (HOMA-IR) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hormones | FSTL3 | IGF-1 to iIGFBP3 | FSTL3 | IGF-1 to iIGFBP3 | FSTL3 | IGF-1 to iIGFBP3 | FSTL3 | IGF-1 to iIGFBP3 | FSTL3 | IGF-1 to iIGFBP3 | |
| SS vs NASH | Exp(B) | 4.89 | 0.36 | 4.97 | 0.39 | 7.78 | 0.40 | 9.00 | 0.42 | 5.82 | 0.44 |
| 95% CI | 1.2–20.1 | 0.1–1.0 | 1.2–21.1 | 0.1–1.1 | 1.3–44.7 | 0.1–1.1 | 1.3–61.3 | 0.2–1.2 | 0.9–35.9 | 0.2–1.2 | |
| P-value* | .03 | .06 | .03 | .08 | .02 | .08 | .03 | 0.10 | 0.06 | 0.12 | |
| Steatosis | Exp(B) | 3.09 | 0.66 | 3.07 | 0.52 | 3.26 | 0.51 | 3.36 | 0.62 | 2.42 | 0.90 |
| (≤33% or >33%) | 95% CI | 1.1–8.8 | 0.3–1.7 | 1.1–8.9 | 0.2–1.4 | 1.0–10.7 | 0.2–1.4 | 1.0–11.6 | 0.2–1.8 | 0.8–7.6 | 0.4–2.3 |
| P-value* | .04 | .38 | .04 | .21 | .05 | .20 | .06 | 0.39 | 0.13 | 0.82 | |
| Lobular inflammation | Exp(B) | 4.58 | 0.64 | 4.52 | 0.74 | 11.4 | 0.75 | 12.1 | 0.88 | 4.11 | 0.82 |
| (absent vs present) | 95% CI | 1.3–16.1 | 0.3–1.6 | 1.3–16.1 | 0.3–1.9 | 1.7–77.3 | 0.3–1.9 | 1.6–91.0 | 0.3–2.4 | 0.9–18.7 | 0.3–2.1 |
| P-value* | .02 | .33 | .02 | .53 | .01 | .53 | .02 | 0.88 | 0.07 | 0.67 | |
| Portal inflammation | Exp(B) | 4.30 | 0.48 | 4.72 | 0.55 | 8.77 | 0.53 | 9.31 | 0.54 | 3.90 | 0.63 |
| (none to minimal vs | 95% CI | 1.2–14.9 | 0.2–1.3 | 1.3–17.5 | 0.2–1.6 | 1.5–51.1 | 0.2–1.6 | 1.5–59.5 | 0.2–1.6 | 1.1–14.1 | 0.2–1.7 |
| greater than minimal) | P-value* | .02 | .15 | .02 | .26 | .02 | .26 | .02 | 0.28 | 0.04 | 0.35 |
| Ballooning | Exp(B) | 2.36 | 0.38 | 2.34 | 0.40 | 2.65 | 0.39 | 2.64 | 0.35 | 2.36 | 0.39 |
| (absent vs present) | 95% CI | 0.6–9.9 | 0.1–1.2 | 0.6–9.7 | 0.1–1.3 | 0.6–11.9 | 0.1–1.3 | 0.6–11.9 | 0.1–1.3 | 0.4–12.9 | 0.1–1.3 |
| P-value* | .24 | .11 | .24 | .13 | .21 | .13 | .21 | 0.12 | 0.32 | 0.14 | |
| Fibrosis | Exp(B) | 1.78 | 0.37 | 1.78 | 0.39 | 1.93 | 0.39 | 2.00 | 0.42 | 1.44 | 0.42 |
| (absent vs present) | 95% CI | 0.7–4.8 | 0.1–1.0 | 0.7–4.8 | 0.1–1.1 | 0.7–5.6 | 0.1–1.1 | 0.6–6.3 | 0.1–1.3 | 0.4–4.9 | 0.1–1.3 |
| P-value* | .25 | .06 | .25 | .08 | .23 | .08 | .23 | 0.12 | 0.56 | 0.12 |
Age and HOMA IR values were not normally distributed and were therefore logarithmically transformed before entering into the analysis.
*Exp(B): corresponds to one SD increase. P-values refer to FSTL3 or IGF-1 to iIGFBP3 (intact IGFBP3).