Table 3.
SOX2 binding sites in known IGD genes and changes after depletion of RMST
| SOX2 binding site | SOX2 binding site (absence of RMST) | |
|---|---|---|
| KAL1 | No | No |
| NROB1(DAX1) | chrX:30237372:30237587 | No |
| GNRHR | No | No |
| PCSK1 | No | No |
| LEP | No | No |
| FGFR1 | chr8:38444431:38445018 | No |
| KISS1R | No | No |
| NSFM(NELF) | No | No |
| PROKR2 | No | chr20:5243291:5244788 |
| PROK2 | No | No |
| LEPR | chr1:65658276:65658800 | No |
| FGF8 | No | No |
| CHD7 | No | No |
| GNRH1 | No | No |
| TAC3 | chr12:55696425:55696910 | No |
| TACR3 | chr4:104859805:104860418 | chr4:104859537:104861056 |
| WDR11 | No | No |
| HS6ST1 | No | No |
| POLR3B | No | No |
| KISS1 | No | No |
| SEMA3A | No | No |
| FGF17 | No | No |
| IL17RD | chr3:57173766:57174183 | No |
| SPRY4 | No | No |
| DUSP6 | chr12:88270267:88270887 | No |
| FLRT3 | chr20:14266025:14266376 | chr20:14265925:14266584 |
| SOX10 | chr22:36709222:36709997 | No |
| OTUD4 | chr4:146320233:146320452 | No |
| RNF216 | chr7:5787630:5788029 | No |
| TUBB3 | chr16:88516780:88517669 | chr16:88517627:88518915 |
| FEZF1 | chr7:121731148:121731552 | No |
| PNPLA6 | No | No |
| STUB1 | No | No |
| AXL | No | No |
| MKRN3 | chr15:21361791:21362052 | No |
From the 35 known IGD genes, 15 contain a SOX2 binding site. Upon deletion of RMST, the SOX2 binding sites disappear in 12 of 15 genes including FGFR1, TAC3, NROB1, LEPR, SOX10, RNF216, OTUD4, FEZF1, MKRN3, MCM4, IL17RD, and DUSP6. On the other hand, SOX2 binding sites of TACR3, TUBB3, and FLRT3 were not altered upon deletion of RMST and 1, PROKR2, gained 1 SOX2 binding site.