Table 6.

Multivariate logistic regression analysis of factors associated with ≥ grade 3 adverse events

	Odds ratio (95% CI)	P‐value
Age (< 75 vs. ≥ 75)	3.440 (0.804–14.700)	0.096
Smoking history (No vs. Yes)	1.520 (0.317–7.290)	0.601
BSA (≥ 1.5 vs. < 1.5)	2.040 (0.427–9.710)	0.372
CCr (mL/min)† or eGFR (mL/min/1.73 m2)‡ (≥60 vs. <60)	0.487 (0.113–2.110)	0.336
ECOG PS (0–1 vs. ≥ 2)	2.230 (0.386–12.900)	0.370
Treatment lines (second‐ vs. third−/later‐line)	1.340 (0.313–5.770)	0.691

^† CCr was calculated using the Cockcroft and Gault (CG) equation for glomerular filtration rate (GFR) estimation.

^‡ eGFR was determined using the Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) creatinine‐based equation.

BSA, body surface area; CCr, creatinine clearance; ECOG, Eastern Cooperative Oncology Group; eGFR, estimated glomerular filtration rate; PFS, progression‐free survival; PS, performance status.