FIG 3.

Variant coordinate search with CIViCpy. (A) Querying GENIE variants against the CIViC knowledgebase results in 7.6% (n = 34,642) of variant (n = 445,655) and 46.3% (n = 27,545) of tumors (n = 59,437) with Exact matches to CIViC variants. Allowing for Any matches, these values increase to 50.5% of variants (n = 229,991) and 86.6% of tumors (n = 51,470). A small percentage (8.7%; n = 5,200) of all tumors had no reported variants with which to search. (B) Tumors were grouped by the number of variants that Exact matched CIViC records. For each tumor, the highest level of evidence supporting the matched variants was counted. We observed that 83.3% of tumors (n = 22,950) with Exact matching variants (which equates to 38.6% of all tumors) were linked to CIViC Validated (Level A) or Clinical (Level B) evidence. (C) Response time of CIViCpy bulk queries against the CIViC knowledgebase. As the number of variants queried increase > 1,000, response time is linear to the number of queries, with an increase in overall time of 0.808 ms/variant. CIViC, Clinical Interpretations for Variants in Cancer.