Table 3.

Comparison of results from pooled individual-level data analysis and distributed regression analysis based on data from 34 healthcare organizations, organized into 27 distinct network partners (or distinct databases), in the PCORnet Antibiotics and Childhood Growth Study, by antibiotic exposure classification. Each model included all the covariates listed in Table 1 plus 26 indicator variables for network partners.

No Complex Chronic Condition (n=304,868)						With Complex Chronic Condition (n=51,413)
		Pooled Individual-level Data Analysis		Distributed Regression				Pooled Individual-level Data Analysis		Distributed Regression
	Episodes	Parameter Estimate	Standard Error	Parameter Estimate	Standard Error		Episodes	Parameter Estimate	Standard Error	Parameter Estimate	Standard Error
Any antibiotic exposure (Model 1)		0.03419	0.00478	0.03419	0.00478	Any antibiotic exposure (Model 2)		0.05774	0.01302	0.05774	0.01302
Broad spectrum (Model 3)		0.04037	0.00474	0.04037	0.00474	Broad-spectrum (Model 4)		0.06680	0.01290	0.06680	0.01290
Narrow spectrum (Model 5)		0.01978	0.00583	0.01978	0.00583	Narrow-spectrum (Model 6)		0.02435	0.01810	0.02435	0.01810
Systemic antibiotic prescribing episodes (Model 7)	0	REF	REF	REF	REF	Systemic antibiotic prescribing episodes (Model 8)	0	REF	REF	REF	REF
	1	0.01327	0.00574	0.01327	0.00574		1	0.02715	0.01607	0.02715	0.01607
	2	0.03853	0.00701	0.03853	0.00701		2	0.06950	0.01957	0.06950	0.01957
	3	0.04646	0.00843	0.04646	0.00843		3	0.06892	0.02356	0.06892	0.02356
	4+	0.06890	0.00701	0.06890	0.00701		4+	0.09635	0.01853	0.09635	0.01853
Systemic broad-spectrum antibiotic prescribing episodes (Model 9)	0	REF	REF	REF	REF	Systemic broad-spectrum antibiotic prescribing episodes (Model 10)	0	REF	REF	REF	REF
	1	0.03229	0.0058	0.03229	0.0058		1	0.04039	0.01596	0.04039	0.01596
	2	0.04542	0.00837	0.04542	0.00837		2	0.06685	0.02182	0.06685	0.02182
	3	0.03256	0.01116	0.03256	0.01116		3	0.14779	0.02763	0.14779	0.02763
	4+	0.06760	0.00938	0.06760	0.00938		4+	0.08664	0.02207	0.08664	0.02207
Systemic narrow-spectrum antibiotic prescribing episodes (Model 11)	0	REF	REF	REF	REF	Systemic narrow-spectrum antibiotic prescribing episodes (Model 12)	0	REF	REF	REF	REF
	1	0.01341	0.00661	0.01341	0.00661		1	0.01285	0.02104	0.01285	0.02104
	2	0.02940	0.00972	0.02940	0.00972		2	0.07939	0.03227	0.07939	0.03227
	3	0.02605	0.01528	0.02605	0.01528		3	0.02877	0.05172	0.02877	0.05172
	4+	0.05771	0.02098	0.05771	0.02098		4+	−0.06616	0.06041	−0.06616	0.06041