Table 3.
Results of Multivariable Linear Mixed Effects Model Assessing the Effect of Corneal Hysteresis on Anterior Lamina Cribrosa Surface (ALCS) Displacement (adjusting for confounders)
| Parameter | Effect on slope (model 1) | Effect on slope (model 2) | Effect on slope (model 3) | |||
|---|---|---|---|---|---|---|
| β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | |
| Age (per 10 year older) | −0.22 (−1.52, 1.09) | 0.747 | −0.19 (−1.5, 1.11) | 0.772 | 0.29 (−1.09, 1.67) | 0.685 |
| Average IOP (per mm Hg higher) | −0.12 (−0.44, 0.2) | 0.468 | - | - | - | - |
| Peak IOP (per mm Hg higher) | - | - | −0.08 (−0.31,0.15) | 0.516 | - | - |
| IOP change (per mm Hg higher) | - | - | - | - | 0.35 (0.02, 0.69) | 0.037 |
| Baseline CCT (per 10 μm thinner) | −0.08 (−0.36, 0.19) | 0.554 | −0.07 (−0.33, 0.2) | 0.616 | −0.05 (−0.32, 0.23) | 0.742 |
| Choroidal Thickness (per 10 μm thinning) | −0.3 (−0.57, −0.03) | 0.032 | −0.29 (−0.56, −0.02) | 0.037 | −0.31 (−0.6, −0.02) | 0.034 |
| CH (per 1 mm Hg lower) | 0.75 (0.07, 1.42) | 0.031 | 0.73 (0.06, 1.39) | 0.033 | 0.66 (0, 1.32) | 0.048 |
P<0.05 are shown as bold
CCT: central corneal thickness; CH: corneal hysteresis; CI: confidence interval; IOP: intraocular pressure
Coefficient β corresponds to the effect on change over time. Positive values correspond to posterior ALCS displacement over time while negative values correspond to anterior ALCS displacement over time.