Table 5.
Negative binomial regression models for the association between baseline SLICC-FI values and the change in the SDI during follow-up among SLE patients, stratified by follow-up time.
| Univariable model | Full multivariable model a | |
|---|---|---|
| Incidence Rate Ratio b (95% CI) |
Incidence Rate Ratio b (95% CI) |
|
| Cut point: 2.5 years follow-up | ||
| ≤ 2.5 years follow-up (n=188) | 1.09 (0.91 – 1.30) | 0.93 (0.77 – 1.11) |
| > 2.5 years follow-up (n=1361) | 1.27 (1.21 – 1.34) | 1.22 (1.16 – 1.29) |
| Cut point: 5.0 years follow-up | ||
| ≤ 5.0 years follow-up (n=486) | 1.23 (1.11 – 1.36) | 1.15 (1.04 – 1.27) |
| > 5.0 years follow-up (n=1063) | 1.26 (1.19 – 1.33) | 1.22 (1.15 – 1.29) |
| Cut point: 7.5 years follow-up | ||
| ≤ 7.5 years follow-up (n=825) | 1.22 (1.14 – 1.32) | 1.14 (1.06 – 1.22) |
| > 7.5 years follow-up (n=724) | 1.30 (1.22 – 1.37) | 1.25 (1.17 – 1.34) |
| Cut point: 10.0 years follow-up | ||
| ≤ 10.0 years follow-up (n=1184) | 1.26 (1.19 – 1.33) | 1.18 ( 1.12 – 1.26) |
| > 10.0 years follow-up (n=365) | 1.27 (1.17 – 1.38) | 1.22 (1.12 – 1.34) |
| Cut point: 12.5 years follow-up | ||
| ≤ 12.5 years follow-up (n=1395) | 1.25 (1.18 – 1.32) | 1.19 (1.13 – 1.25) |
| > 12.5 years follow-up (n=154) | 1.42 (1.25 – 1.62) | 1.35 (1.16 – 1.56) |
a
Models adjusted for the following baseline characteristics: age, sex, steroid use, antimalarial use, immunosuppressive use, ethnicity/location, post-secondary education, and SLEDAI-2K.
b
All incidence rate ratios are per 0.05 increase in baseline SLICC-FI score
Notes: SLICC = Systemic Lupus International Collaborating Clinics; FI = Frailty Index; SDI = SLICC / ACR Damage Index; LR = Likelihood Ratio