Fig. 2.

Altered expression level of UPR signaling pathway- related ER transmembrane stress sensor proteins in schizophrenia. Protein expression of UPR signaling pathway-related proteins was measured in paired schizophrenia (SCZ) and comparison (COMP) subjects. a Representative western blots are shown for paired comparison and schizophrenia subjects. b Increased expression was observed for BiP, and decreased expression was observed for PERK, and p-IRE1α, though the ratio of p-IRE1α to total IRE1α was not significantly different. c BiP, PERK, p-IRE1α, and the ratio of p-IRE1α to total IRE1α expression were not significantly different between rats that had received chronic haloperidol (HAL) treatment and those that were vehicle treated (VEH). Data are expressed as means ± SEM. *p < 0.05, ***p < 0.001, ****p < 0.0001