Table 1.
Chromogenic organic solvents as reported by Gerarde126 from his experimental animal studies using a single subcutaneous injection of the listed substances of unknown purity in a dose of approximately 5 ml/kg. Gerarde reported that treatment of male and female rats and hamsters with 1,2-diethylbenzene (1,2-DEB) or 1,3-diethylbenzene (1,3-DEB), but not 1,4-diethylbenzene (1,4-DEB), caused the excretion of a blue dye in the urine. The sclera, blood, plasma and tissues were stained a deep blue that persisted for many days. Later work using purified compounds found that 1,2-DEB (95%) and DEB mixtures,127 but not 1,3-DEB (99%) or 1,4-DEB (96%) alone, were chromogenic in rats given repeated oral doses of 500 and 750 mg/kg/day, 5 days/week for 10 weeks.46,49 Humans may also excrete colored (green) urine following exposure to tetralin,127 and a blue discoloration of the skin and internal organs develops in rodents repeatedly treated with acetylethyltetramethyltetralin.56,57
Monocyclic | Dicyclic |
---|---|
1,2-Xylene | Indene |
1,2-Ethyltoluene | Tetralin |
1,2-Diethylbenzene | Diphenyl |
1,3-Diethylbenzene | Diphenylmethane |
1,2-Diisopropylbenzene | 1-Methylnaphthalene |
Triethylbenzene (mixture) | 2-Methylnaphthalene |
Diethyldisopropylbenzene | 1-Ethylnaphthalene |
Indane | 2-Ethylnaphthalene |