. 2020 Mar 1;27(3):226–244. doi: 10.5551/jat.49536

Supplementary Table 7. Stratification analysis by age, gender, smoking and drinking status for the association of ACTB with hypertension and stroke in the follow-up study.

End Point	SNP	Stratum	Genotype	N	Person-years	Incidence density (/10⁴ Person-years)	HR (95% CI)
End Point	SNP	Stratum	Genotype	N	Person-years	Incidence density (/10⁴ Person-years)	Additive model	Dominant model	Recessive model
Hypertension	rs852426	Male	TT	150	2154.16	696.33	1.106 (0.899–1.361)^a	1.204 (0.940–1.542)^a	0.754 (0.384–1.481)^a
			TC	107	1269.52	842.84	P = 0.341	P = 0.142	P = 0.413
			CC	9	159.13	565.58
		Female	TT	207	3317.79	623.91	1.172 (0.969–1.418)^a	1.148 (0.924–1.426)^a	1.599 (0.942–2.714)^a
			TC	125	1900.87	657.59	P = 0.101	P = 0.214	P = 0.082
			CC	15	187.45	800.21
		<55 years	TT	105	2225.96	471.71	1.120 (0.872–1.438)^a	1.169 (0.868–1.575)^a	1.011 (0.491–2.085)^a
			TC	70	1331.86	525.58	P = 0.376	P = 0.304	P = 0.975
			CC	8	157.06	509.36
		≥ 55 years	TT	252	3245.98	776.34	1.166 (0.986–1.378)^a	1.201 (0.989–1.459)^b	1.158 (0.700–1.914)^b
			TC	162	1838.53	881.14	P = 0.072	P = 0.065	P = 0.568
			CC	16	189.53	844.19
		Smoking	TT	85	1364.35	623.01	1.127 (0.856–1.485)^c	1.248 (0.902–1.726)^c	0.636 (0.231–1.751)^c
			TC	70	787.22	889.21	P = 0.394	P = 0.181	P = 0.381
			CC	4	83.65	478.18
		Non-smoking	TT	272	4107.6	662.19	1.102 (0.935–1.299)^c	1.090 (0.901–1.319)^c	1.312 (0.833–2.065)^c
			TC	162	2383.18	679.76	P = 0.245	P = 0.373	P = 0.241
			CC	20	262.94	760.63
		Drinking	TT	86	1193.82	720.38	1.130 (0.854–1.496)^d	1.214 (0.870–1.693)^d	0.872 (0.375–2.025)^d
			TC	63	709.91	887.44	P = 0.392	P = 0.254	P = 0.749
			CC	6	86.02	697.51
		Non-drinking	TT	271	4284.35	632.53	1.144 (0.972–1.347)^d	1.159 (0.960–1.399)^d	1.233 (0.764–1.990)^d
			TC	169	2460.48	686.86	P = 0.105	P = 0.126	P = 0.390
			CC	18	260.57	690.79
	rs852423	Male	AA	119	1768.20	673.00	1.141 (0.952–1.368)^a	1.334 (1.044–1.705)^a	0.841 (0.536–1.320)^a
			AG	126	1448.11	870.10	P = 0.153	P = 0.021	P = 0.451
			GG	21	366.50	572.99
		Female	AA	171	2758.35	619.94	1.116 (0.948–1.315)^a	1.056 (0.854–1.306)^a	1.466 (1.038–2.068)^a
			AG	137	2139.39	640.37	P = 0.188	P = 0.612	P = 0.030
			GG	38	508.40	747.44
		<55 years	AA	82	1859.30	441.03	1.261 (1.008–1.578)^b	1.265 (0.941–1.701)^b	1.581 (0.985–2.539)^b
			AG	81	1503.42	538.77	P = 0.043	P = 0.120	P = 0.058
			GG	20	352.17	567.91
			GG	20	352.17	567.91
		≥ 55 years	AA	208	2667.25	779.83	1.072 (0.929–1.238)^b	1.135 (0.938–1.373)^b	0.984 (0.706–1.371)^b
			AG	181	2084.08	868.49	P = 0.340	P = 1.135	P = 0.924
			GG	39	522.74	746.07
		Smoking	AA	69	1138.23	606.20	1.155 (0.906–1.473)^c	1.267 (0.919–1.746)^c	1.212 (0.890–1.650)^c
			AG	77	886.57	868.51	P = 0.246	P = 0.148	P = 0.222
			GG	13	210.41	617.84
		Non-smoking	AA	221	3388.32	652.24	1.092 (0.948–1.259)^c	1.088 (0.904–1.310)^c	1.018 (0.572–1.814)^c
			AG	186	2700.92	688.65	P = 0.222	P = 0.373	P = 0.951
			GG	46	664.49	692.26
		Drinking	AA	65	973.00	668.04	1.208 (0.950–1.535)^d	1.392 (0.999–1.940)^d	1.036 (0.600–1.789)^d
			AG	75	811.04	924.74	P = 0.124	P = 0.051	P = 0.898
			AG	75	811.04	924.74	P = 0.124	P = 0.051	P = 0.898
		Non-drinking	AA	225	3559.53	632.11	1.099 (0.953–1.267)^d	1.099 (0.914–1.322)^d	1.216 (0.887–1.663)^d
			AG	188	2776.46	677.12	P = 0.192	P = 0.316	P = 0.225
			GG	44	669.43	657.28
	rs2966449	Male	TT	143	2002.44	714.13	1.072 (0.882–1.303)^a	1.179 (0.923–1.506)^a	0.769 (0.439–1.346)^a
			TC	110	1343.78	818.59	P = 0.486	P = 0.187	P = 0.357
			CC	13	233.50	556.75
		Female	TT	195	3040.83	641.27	1.000 (0.835–1.199)^a	0.981 (0.792–1.215)^a	1.110 (0.686–1.795)^a
			TC	134	2052.30	652.93	P = 0.997	P = 0.861	P = 0.671
			CC	18	313.03	575.02
		<55 years	TT	103	2070.92	497.36	1.020 (0.797–1.307)^b	1.010 (0.750–1.359)^b	1.100 (0.576–2.102)^b
			TC	70	1426.06	490.86	P = 0.873	P = 0.950	P = 0.772
			CC	10	209.84	476.55
		≥ 55 years	TT	235	2972.36	790.62	1.055 (0.903–1.233)^b	1.122 (0.927–1.358)^b	0.842 (0.542–1.308)^b
			TC	174	1970.02	883.24	P = 0.501	P = 0.238	P = 0.444
			CC	21	336.69	623.72
		Smoking	TT	85	1271.34	668.59	1.073 (0.825–1.395)^c	1.152 (0.836–1.587)^c	0.819 (0.378–1.775)^c
			TC	67	837.37	800.12	P = 0.598	P = 0.387	P = 0.613
			CC	7	123.41	567.21
		Non-smoking	TT	253	3771.93	670.74	0.999 (0.855–1.168)^c	1.001 (0.831–1.207)^c	0.988 (0.652–1.495)^c
			TC	177	2558.71	691.75	P = 0.993	P = 0.988	P = 0.955
			CC	24	423.12	567.21
		Drinking	TT	82	1094.57	749.15	1.080 (0.831–1.402)^d	1.092 (0.786–1.516)^d	1.128 (0.602–2.117)^d
			TC	62	757.97	817.97	P = 0.566	P = 0.601	P = 0.707
			CC	11	137.20	801.75
		Non-drinking	TT	256	3954.92	647.30	1.013 (0.867–1.184)^d	1.049 (0.868–1.260)^d	0.865 (0.551–1.358)^d
			TC	182	2638.10	689.89	P = 0.870	P = 0.636	P = 0.529
			CC	20	409.32	488.62
Stroke	rs852426	Male	TT	54	5271.40	102.44	0.908 (0.622–1.325)^a	0.900 (0.583–1.387)^a	0.860 (0.268–2.756)^a
			TC	36	2981.01	120.76	P = 0.617	P = 0.632	P = 0.799
			CC	3	420.76	71.30
		Female	TT	52	7670.07	67.80	1.287 (0.902–1.836)^a	1.340 (0.870–2.064)^a	1.442 (0.561–3.705)^a
			TC	33	4393.60	75.11	P = 0.164	P = 0.184	P = 0.447
			CC	5	484.35	103.23
		<55 years	TT	7	4766.93	14.68	1.308 (0.406–4.214)^b	1.603 (0.417–6.156)^b	-
			TC	5	2630.37	19.01	P = 0.653	P = 0.492	-
			CC	0	313.26	-
		≥ 55 years	TT	99	8174.54	121.11	1.059 (0.815–1.376)^b	1.068 (0.783–1.456)^b	1.086 (0.529–2.229)^b
			TC	64	4744.24	134.90	P = 0.666	P = 0.679	P = 0.823
			CC	8	591.85	135.17
		Smoking	TT	29	3202.08	90.57	0.734 (0.408–1.322)^c	0.711 (0.369–1.372)^c	0.627 (0.085–4.652)^c
			TC	16	1824.74	87.68	P = 0.303	P = 0.309	P = 0.648
			CC	1	212.43	47.07
		Non-smoking	TT	77	9739.39	79.06	1.167 (0.873–1.558)^c	1.193 (0.843–1.689)c 1.241	(0.573–2.686)^c
			TC	53	5549.87	95.50	P = 0.296	P = 0.319	P = 0.584
			CC	7	692.68	101.06
		Drinking	TT	29	2799.11	103.60	0.470 (0.227–0.975)^d	0.473 (0.219–1.020)^d	-
			TC	11	1643.04	66.95	P = 0.042	P = 0.056	-
			CC	0	233.57	-
		Non-drinking	TT	77	10142.37	75.92	1.278 (0.969–1.686)^d	1.319 (0.943–1.847)^d	1.448 (0.704–2.979)^d
			TC	58	5731.56	101.19	P = 0.083	P = 0.106	P = 0.314
			CC	8	671.54	119.13
			CC	8	671.54	119.13
	rs852423	Male	AA	41	4335.75	94.56	1.179 (0.856–1.624)^a	1.304 (0.851–2.000)^a	1.055 (0.505–2.203)^a
			AG	44	3432.82	128.17	P = 0.313	P = 0.223	P = 0.884
			GG	8	898.40	89.05
		Female	AA	42	6368.86	65.95	1.200 (0.884–1.628)^a	1.314 (0.862–2.202)^a	1.175 (0.600–2.300)^a
			AG	38	4972.19	76.43	P = 0.243	P = 0.204	P = 0.638
			GG	10	1206.99	82.85
		<55 years	AA	6	3894.35	15.41	1.055 (0.364–3.057)^b	1.543 (0.384–6.209)^b	-
			AG	6	3088.90	19.42	P = 0.921	P = 0.541	-
			GG	0	721.09	-
		≥ 55 years	AA	77	6810.25	113.06	1.182 (0.946–1.478)^b	1.298 (0.956–1.763)^b	1.120 (0.685–1.833)^b
			AG	76	5316.10	142.96	P = 0.142	P = 0.095	P = 0.651
			GG	18	1384.29	130.03
		Smoking	AA	22	2649.69	83.03	0.893 (0.549–1.454)^c	0.977 (0.528–1.809)^c	0.522 (0.125–2.177)^c
			AG	22	2068.29	106.37	P = 0.650	P = 0.941	P = 0.372
			GG	2	515.05	38.83
		Non-smoking	AA	61	8054.91	75.73	1.254 (0.978–1.607)^c	1.370 (0.971–1.934)^c	1.290 (0.762–2.184)^c
			AG	60	6336.72	94.69	P = 0.074	P = 0.073	P = 0.342
			GG	16	1590.34	100.61
		Drinking	AA	19	2269.49	83.72	1.192 (0.718–1.979)^d	1.499 (0.760–2.955)^d	0.669 (0.159–2.814)^d
			AG	19	1893.11	100.36	P = 0.496	P = 0.242	P = 0.583
			GG	2	506.90	39.46
		Non-drinking	AA	64	8435.11	75.87	1.207 (0.946–1.541)^d	1.307 (0.934–1.829)^d	1.218 (0.721–2.057)^d
			AG	63	6511.89	96.75	P = 0.130	P = 0.119	P = 0.460
			GG	16	1598.48	100.10
	rs2966449	Male	TT	46	4881.39	94.24	1.325 (0.945–1.859)^a	1.436 (0.940–2.194)^a	1.308 (0.561–3.051)^a
			TC	41	3256.39	125.91	P = 0.103	P = 0.094	P = 0.534
			CC	6	529.21	113.38
		Female	TT	52	7127.86	72.95	0.759 (0.521–1.104)^a	0.794 (0.516–1.222)^a	0.348 (0.083–1.464)^a
			TC	36	4709.80	76.44	P = 0.149	P = 0.294	P = 0.150
			CC	2	710.40	28.15
		<55 years	TT	8	4438.70	18.02	0.706 (0.194–2.570)^b	0.754 (0.186–3.050)^b	-
			TC	4	2828.25	14.14	P = 0.597	P = 0.692	-
			CC	0	432.45	-
		≥ 55 years	TT	90	7570.55	118.88	1.066 (0.828–1.371)^b	1.131 (0.833–1.535)^b	0.855 (0.417–1.755)^b
			TC	73	5137.94	142.08	P = 0.620	P = 0.429	P = 0.670
			CC	8	807.16	99.11
		Smoking	TT	27	2950.55	91.51	0.804 (0.461–1.400)^c	0.810 (0.432–1.516)^c	0.548 (0.074–4.076)^c
			TC	18	2014.60	89.35	P = 0.441	P = 0.509	P = 0.557
			CC	1	267.90	37.33
		Non-smoking	TT	71	9058.70	78.38	1.077 (0.813–1.428)^c	1.143 (0.811–1.612)^c	0.888 (0.408–1.933)^c
			TC	59	5951.58	99.13	P = 0.605	P = 0.445	P = 0.765
			CC	7	971.71	72.04
		Drinking	TT	26	2558.70	101.61	0.768 (0.419–1.408)^d	0.853 (0.434–1.675)^d	-
			TC	14	1806.60	77.49	P = 0.394	P = 0.644	-
			CC	0	310.42	-
		Non-drinking	TT	72	9450.55	76.19	1.096 (0.832–1.442)^d	1.152 (0.823–1.612)^d	0.969 (0.466–2.015)^d
			TC	63	6159.58	102.28	P = 0.515	P = 0.410	P = 0.933
			CC	8	929.19	86.10

Adjusted for age, BMI, HDL-C, LDL-C, TC, TG, smoking status, drinking status and T2DM.

Adjusted for gender, BMI, HDL-C, LDL-C, TC, TG, smoking status, drinking status and T2DM.

Adjusted for age, gender, BMI, HDL-C, LDL-C, TC, TG, drinking status and T2DM.

Adjusted for age, gender, BMI, HDL-C, LDL-C, TC, TG, smoking status and T2DM.

Adjusted for age, BMI, HDL-C, LDL-C, TC, TG, smoking status, drinking status, T2DM and hypertension.

Adjusted for gender, BMI, HDL-C, LDL-C, TC, TG, smoking status, drinking status, T2DM and hypertension.

Adjusted for age, gender, BMI, HDL-C, LDL-C, TC, TG, drinking status, T2DM and hypertension.

Adjusted for age, gender, BMI, HDL-C, LDL-C, TC, TG, smoking status, T2DM and hypertension