Table 4. Association of rs852426 and drinking with stroke in the nested case-control study.
| Interaction | Model 1 | Model 2 | |
|---|---|---|---|
| Drinking* rs852426 | |||
| HR (95% CI) | 0.721 (0.568, 0.915) | 0.749 (0.575, 0.976) | |
| p | 0.007 | 0.033 | |
| Drinking+rs852426 | |||
| RERI | HR (95% CI) | −0.435 (−0.803, −0.066) | −0.370 (−0.622, −0.118) |
| p | 0.021 | 3.945×10−3 | |
| AP | −0.589 | −0.509 | |
| SI | −1.520 | −2.815 |
HR, hazard ratio; CI, interval confidence; RERI, relative excess risk due to interaction; AP, attributable proportion due to interaction; SI, synergy index
Model 1 did not adjust any covariates.
Model 2 adjusted for age, gender, BMI, HDL-C, LDL-C, TC, TG, smoking status, T2DM and hypertension.