Supplementary Table 4. Association analyses of ACTB with hypertension in the case-control study.
| SNP | Group | WT/HT/MT |
OR (95% CI)a |
Allele gene |
||||
|---|---|---|---|---|---|---|---|---|
| Additive model | Dominant model | Recessive model | Major/minor | OR (95% CI)/Pb | Pc | |||
| rs852426 | TT/TC/CC | T/C | ||||||
| Case | 1217/696/99 | 1.036 (0.929–1.156) | 1.006 (0.884–1.144) | 1.282 (0.944–1.740) | 3130/894 | 0.963 (0.869–1.068) | 0.478 | |
| Control | 1342/776/88 | P = 0.521 | P = 0.930 | P = 0.112 | 3460/952 | P = 0.239 | ||
| rs852423 | AA/AG/GG | A/G | ||||||
| Case | 993/809/209 | 1.040 (0.946–1.144) | 1.049 (0.925–1.190) | 1.063 (0.863–1.309) | 2795/1227 | 0.961 (0.874–1.056) | 0.406 | |
| Control | 1119/869/221 | P = 0.413 | P = 0.457 | P = 0.568 | 3107/1311 | P = 0.235 | ||
| rs2966449 | TT/TC/CC | T/C | ||||||
| Case | 1135/763/114 | 0.973 (0.877–1.080) | 0.975 (0.858–1.107) | 0.933 (0.713–1.220) | 3033/991 | 1.005 (0.910–1.110) | 0.924 | |
| Control | 1250/823/134 | P = 0.606 | P = 0.696 | P = 0.612 | 3323/1091 | P = 0.462 | ||
WT, wild type, HT, heterozygote, MT, mutant type.
a
Adjusted for age, gender, body mass index (BMI), glucose (GLU), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG), smoking and drinking status.
b
P value of χ2 test for comparison of allele frequencies between hypertension case and control groups.
c
P value of χ2 test for comparison of genotype between hypertension case and control groups.
The unsuccessful genotyped number of rs852426, rs852423 and rs2966449 was 4, 2 and 3, respectively.