Supplementary Table 5. Stratification analysis by age, gender, smoking and drinking status for the association of ACTB with hypertension in the case-control study.

SNP	Stratum	Group	WT/HT/MT	OR (95% CI)
				Additive model	Dominant model	Recessive model
rs852426			TT/TC/CC
	Male	Case	509/273/47	0.957 (0.810–1.129)a	0.892 (0.729–1.090)a	1.275 (0.818–1.986)a
		Control	527/316/41	P = 0.601	P = 0.263	P = 0.284
	Female	Case	708/423/52	1.115 (0.964–1.289)a	1.110 (0.937–1.315)a	1.316 (0.862–2.009)a
		Control	815/460/47	P = 0.141	P = 0.227	P = 0.204
	<55 years	Case	339/172/23	0.931 (0.765–1.135)b	0.897 (0.711–1.130)b	1.067 (0.610–1.868)b
		Control	521/302/34	P = 0.481	P = 0.356	P = 0.820
	≥ 55 years	Case	878/524/76	1.089 (0.955–1.243)b	1.063 (0.910–1.243)b	1.387 (0.959–2.008)b
		Control	821/474/54	P = 0.202	P = 0.441	P = 0.083
	Smoking	Case	295/161/24	1.010 (0.805–1.267)c	0.931 (0.713–1.217)c	1.633 (0.854–3.123)c
		Control	324/191/18	P = 0.932	P = 0.603	P = 0.138
	Non-smoking	Case	922/535/75	1.046 (0.924–1.185)c	1.030 (0.888–1.194)c	1.209 (0.854–1.711)c
		Control	1018/585/70	P = 0.475	P = 0.695	P = 0.285
	Drinking	Case	256/141/27	1.098 (0.871–1.385)d	0.997 (0.753–1.322)d	1.971 (1.053–3.691)d
		Control	287/171/19	P = 0.429	P = 0.985	P = 0.034
	Non-drinking	Case	961/555/72	1.026 (0.906–1.161)d	1.014 (0.877–1.174)d	1.132 (0.796–1.612)d
		Control	1055/605/69	P = 0.685	P = 0.847	P = 0.490
rs852423			AA/AG/GG
	Male	Case	410/330/88	0.999 (0.863–1.156)a	0.974 (0.800–1.185)a	1.066 (0.776–1.465)a
		Control	439/351/94	P = 0.986	P = 0.790	P = 0.694
	Female	Case	583/479/121	1.079 (0.952–1.223)a	1.116 (0.946–1.316)a	1.069 (0.810–1.412)a
		Control	680/518/127	P = 0.233	P = 0.195	P = 0.636
	<55 years	Case	266/219/48	1.000 (0.842–1.187)b	1.022 (0.816–1.280)b	0.936 (0.635–1.380)b
		Control	434/339/84	P = 0.998	P = 0.849	P = 0.740
	≥ 55 years	Case	727/590/161	1.062 (0.948–1.191)b	1.066 (0.915–1.242)b	1.127 (0.878–1.447)b
		Control	685/530/137	P = 0.298	P = 0.413	P = 0.349
	Smoking	Case	237/192/50	1.057 (0.869–1.285)c	1.012 (0.780–1.312)c	1.271 (0.824–1.960)c
		Control	272/211/50	P = 0.579	P = 0.930	P = 0.278
	Non-smoking	Case	756/617/159	1.037 (0.930–1.156)c	1.059 (0.916–1.223)c	1.020 (0.804–1.295)c
		Control	847/658/171	P = 0.514	P = 0.441	P = 0.870
	Drinking	Case	201/174/48	1.112 (0.906–1.364)d	1.102 (0.837–1.452)d	1.276 (0.822–1.981)d
		Control	235/192/50	P = 0.309	P = 0.489	P = 0.277
	Non-drinking	Case	792/635/161	1.027 (0.923–1.144)d	1.043 (0.904–1.202)d	1.017 (0.801–1.290)d
		Control	884/677/171	P = 0.622	P = 0.567	P = 0.892
rs2966449			TT/TC/CC
	Male	Case	471/313/45	0.916 (0.779–1.076)a	0.921 (0.755–1.122)a	0.805 (0.531–1.220)a
		Control	489/336/58	P = 0.285	P = 0.412	P = 0.306
	Female	Case	664/450/69	1.018 (0.888–1.167)a	1.017 (0.861–1.202)a	1.042 (0.731–1.484)a
		Control	761/487/76	P = 0.800	P = 0.840	P = 0.820
	<55 years	Case	318/186/30	0.917 (0.760–1.106)b	0.871 (0.694–1.094)b	1.046 (0.644–1.697)b
		Control	483/324/48	P = 0.364	P = 0.234	P = 0.856
	≥ 55 years	Case	817/577/84	0.988 (0.870–1.121)b	1.031 (0.883–1.203)b	0.894 (0.648–1.235)b
		Control	767/499/86	P = 0.846	P = 0.701	P = 0.498
	Smoking	Case	269/188/23	1.010 (0.811–1.257)c	1.016 (0.782–1.320)c	0.987 (0.544–1.791)c
		Control	298/207/27	P = 0.931	P = 0.903	P = 0.966
	Non-smoking	Case	866/575/91	0.964 (0.856–1.085)c	0.962 (0.831–1.113)c	0.930 (0.688–1.257)c
		Control	952/616/107	P = 0.544	P = 0.603	P = 0.639
	Drinking	Case	231/167/26	1.022 (0.817–1.279)d	1.027 (0.780–1.354)d	1.027 (0.584–1.807)d
		Control	263/183/31	P = 0.847	P = 0.848	P = 0.925
	Non-drinking	Case	904/596/88	0.966 (0.858–1.087)d	0.963 (0.834–1.112)d	0.938 (0.690–1.275)d
		Control	987/640/103	P = 0.561	P = 0.605	P = 0.683

^aAdjusted for age, BMI, glucose, HDL-C, LDL-C, TC, TG, smoking and drinking status.

^bAdjusted for gender, BMI, glucose, HDL-C, LDL-C, TC, TG, smoking and drinking status.

^cAdjusted for age, gender, BMI, glucose, HDL-C, LDL-C, TC, TG and drinking status.

^dAdjusted for age, gender, BMI, glucose, HDL-C, LDL-C, TC, TG and smoking status.