Fig. 1.

The COX1/2-driven TXA2 pathway is associated with BE and EAC development. a, circulating PG biosynthesis in GERD, BE, and EAC; (1 = non-GERD, n = 15; 2 = GERD, n = 15; 3 = BE, n = 15; and 4 = EAC, n = 15). Plasma samples were collected for measurement of circulating PG levels by using an enzyme immunoassay kit. summary data are presented as means ± S.E. b, Heat map across all the samples showed the PG levels (log2 scale). c, Principal component analysis (PCA) of PG levels. The first two components shown explain the largest part of the variation in PG levels (log2). Individual insets are color-coded by Non GERD (purple), GERD (blue), BE (red) and EAC (Green). d, expression of TBXAS in non-IEN (n = 10), BE with IEN (n = 20), and EAC (n = 10; scale bar 50 μm) patient esophageal samples. e, expression of TBXAS in normal and EAC esophageal tissues (ES809), which include normal adjust esophageal tissues (n = 10), inflamed esophageal tissues (n = 10), and EAC tissues (n = 14). TBXAS protein detection was accomplished using immunohistochemistry. Density scores were obtained for each sample. The asterisks indicate a significant difference compared to the group of control subjects (*, p < 0.05; **, p < 0.01 and ***, p < 0.001, one-way ANOVA).