Table 3.
Odds of occult sentinel lymph node metastasis
| Univariable OR (95% CI) | p value | Adjusteda OR (95% CI) | p value | |
|---|---|---|---|---|
| NLR ≥ 2.3 | 1.2 (0.9, 1.6) | 0.3 | 1.3 (1.3, 1.3) | < 0.001 |
| Angiolymphatic invasion | 4.1 (2.0, 8.4) | < 0.001 | 3.5 (1.9, 6.2) | < 0.001 |
| Microsatellites | 2.8 (1.3, 5.9) | 0.008 | 1.7 (1.4, 2.0) | < 0.001 |
| Mitoses per mm2 | 1.0 (1.0, 1.1) | 0.001 | 1.1 (1.1, 1.1) | < 0.001 |
| Breslow thickness (mm) | 1.1 (1.1, 1.2) | < 0.001 | 1.1 (1.1, 1.2) | < 0.001 |
| Age in years | 1.0 (1.0, 1.0) | 0.010 | 1.0 (1.0, 1.0) | < 0.001 |
| Male | 1.0 (0.8, 1.3) | 0.9 | 1.1 (0.8, 1.5) | 0.7 |
| Ulceration | 1.2 (0.9, 1.6) | 0.4 | 1.1 (0.8, 1.5) | 0.8 |
| Regression | 0.8 (0.5, 1.4) | 0.5 | 0.9 (0.7, 1.2) | 0.5 |
| Anatomical location | ||||
| Head and neck | 1 (referent) | 0.002 | 1 (referent) | 0.01 |
| Upper limb | 1.5 (0.9, 2.7) | 1.5 (0.6, 3.5) | ||
| Lower limb | 2.3 (2.3, 4.0) | 1.8 (0.9, 3.6) | ||
| Trunk and genitals | 2.4 (0.9, 2.7) | 2.5 (1.2, 5.0) | ||
| TILs | ||||
| Absent | 1 (referent) | < 0.001 | 1 (referent) | < 0.001 |
| Non-brisk | 0.7 (0.4, 1.1) | 0.6 (0.6, 0.6) | ||
| Brisk | 0.2 (0.1, 0.5) | 0.2 (0.2, 0.3) |
CI confidence interval, OR odds ratio, TILs tumour-infiltrating lymphocytes
aMixed-effects logistic regression with random-effects varying by the hospital cluster