Table 4.
The risk of recurrent melanoma
| Unadjusted risk | Adjusteda risk | |||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Host factors | ||||
| Neutrophil–lymphocyte ratio | 1.1 (1.0, 1.2) | 0.2 | 0.9 (0.7, 1.1) | 0.2 |
| Age | 1.0 (1.0, 1.0) | 0.008 | 1.0 (1.0, 1.0) | 0.01 |
| Primary tumour factors | ||||
| Breslow thickness | 1.1 (1.1, 1.2) | < 0.001 | 1.1 (1.0, 1.3) | 0.009 |
| Ulceration | 1.5 (1.1, 2.0) | 0.003 | 1.1 (0.6, 2.0) | 0.9 |
| Mitoses per mm2 | 1.0 (1.0, 1.1) | < 0.001 | 1.0 (1.0, 1.0) | 0.1 |
| Angiolymphatic invasion | 3.4 (2.1, 5.5) | < 0.001 | 1.4 (0.7, 2.9) | 0.4 |
| Microsatellites | 2.5 (1.4, 4.2) | 0.001 | 1.8 (0.4, 4.0) | 0.2 |
| Absence of tumour-infiltrating lymphocytes | 4.9 (2.3, 11) | < 0.001 | 5.6 (1.6, 19) | 0.008 |
| Location | ||||
| Trunk and genitals | 1 (referent) | < 0.001 | 1 (referent) | 0.001 |
| Upper limb | 0.7 (0.5, 1.0) | 0.5 (0.3, 0.9) | ||
| Lower limb | 1.4 (1.1, 1.9) | 1.0 (0.6, 1.8) | ||
| Head and neck | 1.4 (1.0, 2.1) | 2.4 (1.3, 4.5) | ||
| Regional node factors | ||||
| Sentinel lymph node metastasis | 5.8 (4.5, 7.3) | < 0.001 | 5.7 (3.8, 8.5) | < 0.001 |
| Extracapsular spread | 1.0 (0.5, 2.0) | 0.9 | – | – |
HR hazard ratio, CI confidence interval
aMultivariable Cox regression with age, Breslow thickness, mitotic rate and NLR modelled as continuous variables, whilst other co-variables were handled as categorical variables