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. 2020 Jan 20;69(4):523–533. doi: 10.1007/s00262-019-02475-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Differential expression of immune-related genes. Upregulated expression of genes related to a antigen presentation. ‘Volcano plot’ of statistical significance against fold-change between primary EAC and normal tissue, demonstrating the significantly differentially expressed genes of MHC class I and II. b Expression of genes related to T-cell function. ‘Volcano plot’ of statistical significance against fold-change between primary EAC and normal tissue, demonstrating the significantly differentially expressed genes, CD3E, CD3G, LAG3, CTLA-4, LILRB1, CD38. c Expression of checkpoint genes. ‘Volcano plot’ of statistical significance against fold-change between primary EAC and normal tissue, demonstrating the significantly differentially expression of PDCD1, CTLA-4, HAVCR2, CD276, LAG3, PDCD1-L1, CD86, BTLA, CD27 and CD28. d Expression of genes related to B-cell function. ‘Volcano plot’ of statistical significance against fold-change between primary EAC and normal tissue, demonstrating the significantly differential expression of B-cell function related genes. Thresholds of significance p-value:1.3 (red line); log2FC: 0.8 (blue lines)