Table 1.

Selected genes which are hypomethylated in HNSSC

Gene	Cancer	Observed connections with hypomethylation	References
WSIP1	OSCC	Higher expression of WSIP1 protein characteristic for patients with lymph node metastasis	Clausen et al. (2016)
CSPG4	HNSCC	Worse clinical outcome Overexpression of mRNA and protein	Warta et al. (2014)
PD-L1	HNSCC	Overexpression of PD-L1 protein	Franzen et al. (2018)
PD-L2	HNSCC	Upregulation of PD-L2 mRNA expression	Franzen et al. (2018)
IL6	OSCC	Upregulation of gene expression	Basu et al. (2017)
PTPN22	OSCC	Upregulation of gene expression	Basu et al. (2017)
RUNX1	OSCC	Upregulation of gene expression	Basu et al. (2017)
CD28	OSCC	Upregulation of gene expression	Basu et al. (2017)
CD22	OSCC	No data related to gene expression	Basu et al. (2017)
CD80	OSCC	Upregulation of gene expression	Basu et al. (2017)
TLR1	OSCC	Upregulation of gene expression	Basu et al. (2017)
TNFa	OSCC	Upregulation of gene expression	Basu et al. (2017)
APEX2	HNSCC	Decreased mRNA expression in tumor	Chaisaingmongkol et al. (2012)
TREX2	HNSCC	No data related to gene expression	Chaisaingmongkol et al. (2012)
MSH4	HNSCC	Decreased mRNA expression in tumor	Chaisaingmongkol et al. (2012)
MIR296	OSCC	No date related to gene expression	Morandi et al. (2017)
TERT	OSCC	No date related to gene expression	Morandi et al. (2017)
GP1BB	OSCC	No date related to gene expression	Morandi et al. (2017)