Table 2.
Selected genes which are hypermethylated in HNSCC
| Gene | Cancer | Observed connections with hypermethylation | References |
|---|---|---|---|
| SALL3 | HNSCC | No data related to gene expression | Chaisaingmongkol et al. (2012) |
| FANCB | HNSCC | No data related to gene expression | Chaisaingmongkol et al. (2012) |
| NEIL1 | HNSCC | Lower gene expression | Chaisaingmongkol et al. (2012) |
| AGTR1 | OSCC | Association with OSCC development | Foy et al. (2015) |
| FOXI2 | OSCC | Association with OSCC development | Foy et al. (2015) |
| PENK | OSCC | Association with OSCC development | Foy et al. (2015) |
| LXN | OSCC | Downregulation of gene expression | Basu et al. (2017) |
| HLA-DPB1 | OSCC | Upregulation of gene expression | Basu et al. (2017) |
| ZNF577 | OSCC | Downregulation of gene expression | Basu et al. (2017) |
| ZNF154 | OSCC | Downregulation of gene expression | Basu et al. (2017) |
| CTDSP1 | OSCC | Downregulation of gene expression | Basu et al. (2017) |
| ZSCAN31 | OSCC | Not significant downregulation of gene expression | Basu et al. (2017) |
| LDLRAD4 | OSCC | Not significant downregulation of gene expression | Basu et al. (2017) |
| NDN | HNSCC | Association with overall survival time | Virani et al. (2015) |
| CD1A | HNSCC | Association with overall survival time | Virani et al. (2015) |
| GRIM-19 | HNSCC | Significant independent risk factor for HNSCC, and Not significant downregulation of gene expression | Zhang et al. (2015b) |
| PTEN | NPC | Downregulation of gene expression | Li et al. (2014a) |
| OSCC | No data related to gene expression | Sushma et al. (2016) | |
| PAX1 | HNSCC | Downregulation of gene expression | Guerrero-Preston et al. (2014); |
| OSCC | No data related to gene expression | Morandi et al. (2017) | |
| PAX5 | HNSCC | Downregulation of gene expression | Guerrero-Preston et al. (2014) |
| ZIC4 | HNSCC | No data related to gene expression | Guerrero-Preston et al. (2014) |
| PLCB1 | HNSCC | No data related to gene expression | Guerrero-Preston et al. (2014) |
| LRPPRC | TSCC | No data related to gene expression | Bhat et al. (2017) |
| RAB6C | TSCC | Downregulation of gene expression | Bhat et al. (2017) |
| ZNF471 | TSCC | Downregulation of gene expression | Bhat et al. (2017) |
| MINT1 | HNSCC | No data related to gene expression | Choudhury and Ghosh (2015) |
| MINT2 | HNSCC | No data related to gene expression | Choudhury and Ghosh (2015) |
| MINT31 | HNSCC | No data related to gene expression | Choudhury and Ghosh (2015) |
| TFPI2 | OSCC | Downregulation of protein expression | Kim et al. (2019) |
| SOX17 | OSCC |
Downregulation of protein expression Association with overall survival time |
Kim et al. (2019) |
| GATA4 | OSCC |
Downregulation of protein expression Association with overall survival time |
Kim et al. (2019) |
| ESRRG | LSCC | Association with overall survival time | Shen et al. (2019) |
| HOXA9 | HNSCC | Possible association with progression and Metastasis of HNSCC | Zhou et al. (2019) |
| ZNF671 | HNSCC |
Downregulation of gene and protein expression Association with overall survival time |
Zhang et al. (2019) |
| RHCG | HNSCC |
Downregulation of gene expression Association with overall survival time |
Xu et al. (2019) |
| SALL1 | HNSCC |
Downregulation of gene expression Association with risk of disease recurrence |
Misawa et al. (2018b) |
| CEACAM6 | LSCC | Downregulation of gene expression | Bednarek et al. (2018) |
| PCDH17 | LSCC | Downregulation of gene expression | Byzia et al. (2018) |
| CPEB4 | HNSC | Downregulation of gene and protein expression | Zeng et al. (2018) |
| CLDN11 | LSCC | Associated with lymph node metastasis, advanced clinical stage, and higher T classification | Shen et al. (2017) |
| SLIT2 | HNSC | Associated with tumor location | Alsofyani et al. (2017) |
| KL | HNSC | Associated with high grade tumor | Alsofyani et al. (2017) |
| SFRP1 | HNSCC | Association with poor survival for patients with moderately differentiated tumor (grade 2) | Alsofyani et al. (2017) |
| PTPRD | LSCC | Downregulation of gene expression | Szaumkessel et al. (2017) |