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. 2020 Feb 12;34(2):183–196. doi: 10.1007/s40259-020-00406-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 3 — Proportion of patients with B-cell depletion below 20% of the LLN a after infusion 1 up to 52 h and b after infusion 2 up to week 24 (PD population). The LLN for B-cell counts in this study was 107.0 cells/μL. 0 (h) at infusion 2 is pre-infusion sample day 15; 3700 (h) at infusion 2 is week 24 with respect to infusion 1. Upper and lower bounds indicated the confidence interval. LLN lower limit of normal, PD pharmacodynamic, MabThera RTX-EU, Rituxan RTX-US