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. 2020 Feb 11;24(2):191–200. doi: 10.1007/s40291-020-00448-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — Example of immunohistochemical staining of a metastatic lymph node and corresponding primary esophageal adenocarcinoma for each tumor marker. Scalebar equals 50 μm. CA-IX carbonic anhydrase IX, CEA carcinoembryonic antigen, c-MET hepatic growth factor receptor, EAC esophageal adenocarcinoma, EGFR epidermal growth factor receptor, EMA epithelial membrane antigen, EpCAM epithelial cell adhesion molecule, HER-2 human epidermal growth factor receptor-2, LNM lymph node metastases, uPAR urokinase plasminogen activator receptor, VEGF-1 vascular endothelial growth factor-1, VEGFR2 VEGF receptor-2