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. 2020 Apr 1;10:5787. doi: 10.1038/s41598-020-62448-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cytotoxic activity of splenocytes against TC1 tumor cells. Mice were vaccinated three times with the each vaccine group or controls at one-week intervals, following inoculation with TC1 tumor cells. The splenocytes were co-cultured with TC1 cells for 6 to 8 h at an effector to target ratio (E:T) of 25:1. The CTL activity of the splenocytes was significantly increased in the mice immunized with pDNA-encapsulated archaeosomes and pDNA-surface localizated archaeosome group compared with that of the pDNA alone (pIRES-L1/E6/E7) and control groups (P < 0.0001). Data on the cytotoxicity induced by different treatments are presented as mean ± SD calculated from three experiments. (Abbreviations: pDNA + (S)Arch: pDNA-surface localized archaeosome; pDNA + (E)Arch: pDNA-encapsulated archaeosomes; pDNA: pDNA alone (L1/E6/E7 recombinant gene); Arch: archaeosomes alone (antigen-free archaeosomes); Mock Plasmid: pIRES.