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. 2020 Mar 26;11:265. doi: 10.3389/fgene.2020.00265

FIGURE 2.

FIGURE 2

Identify modulators of QKI in KIRC. (A) Six mode sub-categories according to the correlation between QKI expression and its target splicing outcomes. The number in the pie chart means the percentage of each sub-categories. AEI indicates attenuates the exon inclusion, AEE indicates attenuates exon exclusion, EEI indicates enhances exon inclusion, EEE indicates enhances exon exclusion, ExonIE indicates reverses exon inclusion to exon exclusion, ExonEI indicates reverse exon exclusion to inclusion. (B) Modulators clusters by their regulation patterns. Six clusters were grouped according to modulator sub-categories. (C) Correlation heatmap of QKI modulators. The redder the color the higher correlation between two modulators. The values in the matrix were the normalized gene expression of modulators. (D) KEGG enrichment analysis of QKI modulators. (E) Modulators categories according to gene biotypes and features, including immune genes, transcription factors and lncRNAs.