TABLE 1.

Categories of modulator mediated RBP regulations on splicing targets.

Modulation category	PCClow	PCChigh	ΔPCCs	Subtype mode
Attenuates splicing	– (EE)	– (EE)	| PCClow| > | PCChigh | or p-value.high > 0.05	Attenuates exon exclusion (AEE)
Enhances splicing	– (EE)	– (EE)	| PCClow| < | PCChigh| or p-value.low > 0.05	Enhances Exon exclusion (EEE)
Inverts splicing	+ (EI)	– (EE)		Exon inclusion to exclusion (ExonIE)
Inverts splicing	– (EE)	+ (EI)		Exon exclusion to inclusion (ExonEI)
Enhances splicing	+ (EI)	++(EI)	| PCClow| < | PCChigh| or p-value. Low > 0.05	Enhances EI (EEI)
Attenuates splicing	+ +(EI)	+(EI)	| PCClow| > | PCChigh| or p-value.high > 0.05	Attenuates EI (AEI)

“+” and “−” signs in the columns indicate positive and negative values of Pearson correlation coefficient. “EE” represents exon exclusion, and “EI” means exon inclusion. The modulation categories of “attenuates splicing.” “enhances splicing” or “inverts splicing” only refer to the roles of RBP on specific alternative spliced exon.