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. 2020 Mar 26;11:272. doi: 10.3389/fphar.2020.00272

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Copyright © 2020 Huang, Ding, Zou, Lu, Wang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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hAFMSCs upregulated the expression level of hGC markers in OPA disease, (A) hAFMSCs increased the number of FSHR⁺AMH⁺ positive hGCs. (B) hAFMSCs increased the number of FOXL2⁺CYP19A1⁺ positive hGCs. (C) hAFMSCs increased the protein level of hGC markers (FSHR, AMH, FOXL2, and CYP19A1). The error bars indicate the SD; **, p < 0.01; ***, p < 0.001; (compared with the OPA group).