Figure 7.
hAFMSCs increase the DNA damage genes in vitro and in vivo. (A) qPCR method revealed that hAFMSCs upregulated the DNA damage genes (γH2AX, BRCA1, PARP1, and XRCC6) to the normal level after co-cultured with OPA hGCs; (B) Western blot method revealed that hAFMSCs upregulated the DNA damage genes to the normal level after co-cultured with OPA hGCs; (C) qPCR assay revealed that hAFMSCs upregulated the DNA damage genes to the normal level after an injection into an OPA mice model; (D) western blot assay revealed that hAFMSCs upregulated the DNA damage genes to the normal level after an injection into an OPA mice model. All of the experiments were carried out three times; the error bars indicate the SD; **p < 0.01; ***p < 0.001 (compared with the OPA group).