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. 2020 Mar 26;11:273. doi: 10.3389/fphys.2020.00273

TABLE 3.

Results of ANOVA and multiple comparisons.

Parameters Testing time (time post de- compression) ANOVA Post Hoc Tests


df F P Groups (vs. Saline group) P
W/D weight ratio 24 h 4 4.120 0.007 UTI-H 0.034
UTI-M 0.352
UTI-L 0.693
Normal 0.001
BALF Protein 24 h 4 5.492 0.001 UTI-H 0.012
UTI-M 0.498
UTI-L 0.675
Normal 0.001
WBC 1 h 3 2.928 0.049 UTI-H 0.006
UTI-M 0.066
UTI-L 0.134
PLT 1 h 3 3.047 0.043 UTI-H 0.005
UTI-M 0.065
UTI-L 0.160
IL-1β 6 h 3 7.195 0.000 UTI-H 0.001
UTI-M 0.018
UTI-L 0.999
MCP-1 12 h 3 6.897 0.000 UTI-H 0.002
UTI-M 0.106
UTI-L 0.181
ET-1 12 h 3 9.554 0.000 UTI-H 0.001
UTI-M 0.011
UTI-L 0.340
ICAM-1 12 h 3 13.733 0.000 UTI-H 0.000
UTI-M 0.000
UTI-L 0.022
MDA 6 h 3 5.560 0.002 UTI-H 0.001
UTI-M 0.174
UTI-L 0.806
MPO 1 h 3 2.799 0.047 UTI-H 0.006
UTI-M 0.083
UTI-L 0.273

Rabbits were subjected to simulated diving to 6 atmospheres absolute (ATA) for 60 min with 2.5-minute decompression, and received intravenous injection of different doses of UTI or saline immediately following decompression. Lung tissues and BALF were sampled for determination of W/D weight ratio and protein content, respectively. Blood was sampled for WBC, PLT and serum indices including IL-1β, MCP-1, ET-1, ICAM-1, MDA, and MPO. Values of the indices were compared between the Saline group and UTI groups at different time points.